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Executive Function

Outcome Cns

Planning, switching between tasks, and holding back a response you are about to make. The last of those is the one that matters here: reported aggression on these compounds is often better described as a failure of the brake than as an increase in anger.

Relationships

3 connections

Executive Function reduces risk of

Aggression

Hostility and short fuse. Reported consistently by users and in case series, and produced in blinded trials mainly at supraphysiological doses and mainly in a minority of people.

Executive Function stimulates

Prefrontal Cortex

Planning, judgement and the brake on impulse. Relevant here because the reported behaviour change on these compounds is often better described as a weaker brake than as a stronger drive, and those two have different consequences.

Serotonin Signalling

How strongly serotonin is signalling. The system most often named when 19-nor androgens are linked to impulse control, irritability and sleep. Almost all of the evidence is rodent work; nothing has been measured at these receptors in a human on these compounds.