Cortical Thickness

Marker Cns

How thick the outer layer of the brain is, measured on MRI. It thins with normal ageing and faster in several dependencies. In steroid users the thinning is regional, and it is concentrated in exactly the areas that handle inhibition.

Relationships

3 connections

Cortical Thickness reduces risk of

Neuronal Apoptosis

Programmed neuron death. Unlike muscle, these cells are largely not replaced, so this process is where a reversible effect becomes a permanent one. Everything protective in this module ultimately resolves to whether it raises or lowers this.

Orbitofrontal Cortex

Where the value of an outcome is weighed against its cost, and the region most consistently thinned in dependent users. This is the specific anatomy behind poor risk judgement.

Cortical Thickness stimulates

Executive Function

Planning, switching between tasks, and holding back a response you are about to make. The last of those is the one that matters here: reported aggression on these compounds is often better described as a failure of the brake than as an increase in anger.

Beyond this page

Cortical Thickness also connects to 2 entries in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.

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