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Prefrontal Cortex

Tissue Cns

Planning, judgement and the brake on impulse. Relevant here because the reported behaviour change on these compounds is often better described as a weaker brake than as a stronger drive, and those two have different consequences.

Relationships

2 connections

Prefrontal Cortex acts in

Dopamine Signalling

How strongly dopamine is signalling, mostly in the reward and motivation circuits. This is the route by which a compound that raises prolactin ends up flattening drive: dopamine holds prolactin down, so a sustained prolactin rise is read backwards as reduced dopaminergic tone.

Prefrontal Cortex stimulates

Executive Function

Planning, switching between tasks, and holding back a response you are about to make. The last of those is the one that matters here: reported aggression on these compounds is often better described as a failure of the brake than as an increase in anger.