G Protein-Coupled Estrogen Receptor

GPER

Receptor Cns

A membrane estrogen receptor separate from ER-alpha and ER-beta. It responds in seconds, which is why some estrogen effects in the brain appear far too fast to be explained by gene transcription.

Relationships

3 connections

G Protein-Coupled Estrogen Receptor expressed in

Hippocampus

Where new memory is laid down. Unusually sensitive to sustained cortisol and to lost deep sleep, both of which these compounds can produce, which makes it the structure behind most reported memory complaints.

Prefrontal Cortex

Planning, judgement and the brake on impulse. Relevant here because the reported behaviour change on these compounds is often better described as a weaker brake than as a stronger drive, and those two have different consequences.

G Protein-Coupled Estrogen Receptor stimulates

Synaptic Plasticity

The brain's ability to strengthen and rebuild connections. It is what learning physically is, and it is the endpoint almost every nootropic peptide claims.

Beyond this page

G Protein-Coupled Estrogen Receptor also connects to 1 entry in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.

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