Glucocorticoid Receptor
GRThe cortisol receptor. Some androgens bind it too, and whether they act as agonist or blocker at a given tissue is a large part of why compounds with similar AR affinity feel so different.
Relationships
5 connectionsGlucocorticoid Receptor expressed in
Adipose Tissue
Stores fat and houses most of the body's aromatase, so more fat mass means more conversion of androgen to estrogen.
Limbic System
The emotional core of the brain, and androgen-receptor rich. This is where mood, threat response and aggression are set, and where steroid mental effects are thought to land.
Skeletal Muscle
The intended target. Dense in androgen receptors, and the tissue where the whole risk trade is being made.
Glucocorticoid Receptor stimulates
Fat Mass
Total body fat. It is the endpoint the whole fat-loss class is measured on, and the one place where the incretin drugs have hard trial data rather than mechanism.
Protein Breakdown
Muscle being taken apart, driven largely by cortisol at the glucocorticoid receptor. Blocking it is the anti-catabolic half of how steroids work.
Beyond this page
Glucocorticoid Receptor also connects to 8 entries in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.
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