Fat Mass
Total body fat. It is the endpoint the whole fat-loss class is measured on, and the one place where the incretin drugs have hard trial data rather than mechanism.
Relationships
5 connectionsFat Mass stimulates
Glucocorticoid Receptor
The cortisol receptor. Some androgens bind it too, and whether they act as agonist or blocker at a given tissue is a large part of why compounds with similar AR affinity feel so different.
HPA Axis Activity
The stress axis: hypothalamus to pituitary to adrenal cortex, ending in cortisol. Relevant to mood twice over. A compound that blocks the glucocorticoid receptor removes the brake the axis runs on, and a compound that shuts down the gonadal axis leaves this one carrying more of the load.
Fat Mass suppresses
Estrogen Receptor alpha
The estrogen receptor that dominates breast tissue, liver and the pituitary feedback loop. Gynecomastia and much of the negative feedback on LH run through it.
Fat Breakdown
Releasing stored fat for fuel. Androgen receptor density on fat cells is part of why some compounds visibly change body composition beyond their muscle effect.
Heat Production
Burning fuel as heat rather than storing it. Raising it increases energy expenditure without requiring more activity, which is the appeal of the glucagon component in the dual and triple agonists.
Beyond this page
Fat Mass also connects to 3 entries in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.
Get your free assessment