GLP-1 Receptor
GLP-1RThe incretin receptor behind semaglutide and every drug in that class. Three separate effects run through it: appetite suppression in the brain, slower stomach emptying, and glucose-dependent insulin release from the pancreas.
Relationships
4 connectionsGLP-1 Receptor expressed in
Heart Muscle
Carries androgen receptors like skeletal muscle does, and thickens under the same signal. Unlike a bicep, a thicker left ventricle fills less well.
Hypothalamus
The control room above the pituitary. Appetite, body temperature, the reproductive axis and the GH rhythm are all set here, which is why so many peptides that produce whole-body effects act on one small area.
Pancreatic Islet
The insulin and glucagon-producing cells. Incretin drugs raise insulin here only when glucose is already high, which is why they do not cause hypoglycaemia on their own the way injected insulin does.
Stomach
Where ghrelin is produced and where GLP-1 agonists slow emptying. That slowing is both the satiety mechanism and the source of the nausea.
Beyond this page
GLP-1 Receptor also connects to 7 entries in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.
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