Bone Marrow
Where red cells are built. Androgens push it harder, which is why they were once a treatment for anaemia and why haematocrit climbs on cycle.
Relationships
5 connectionsBone Marrow expressed in
Androgen Receptor
The receptor every anabolic-androgenic steroid is designed to hit. Binding moves it into the nucleus where it switches on genes for muscle protein synthesis, and in other tissues for hair loss, prostate growth and oil production.
Erythropoietin Receptor
Where EPO tells the bone marrow to make red cells. Separating this from EPO's tissue-protective signalling is the entire design goal of ARA-290: repair without raising haematocrit.
Growth Hormone Receptor
Where growth hormone itself acts. Binding pairs the receptor and fires JAK2/STAT5, which in the liver means IGF-1 output and in fat means lipolysis. Injected GH works here; secretagogues work one step upstream.