Neuroinflammation

Process Cns

Immune activation inside brain tissue. Short bursts are protective. Sustained activation is not, and it limits the very functions the immune cells were maintaining. Estrogen is one of the main brakes on it, which is the mechanistic core of why crashing estrogen has a cost.

Relationships

5 connections

Neuroinflammation increases risk of

Depressed Mood

Low mood, flat drive and anhedonia. Concentrated in the withdrawal window after a cycle, when natural testosterone has not yet restarted.

Neuroinflammation reduces risk of

Blood-Brain Barrier

What decides whether a compound in the blood reaches the brain at all. It is the reason two drugs with the same target can have completely different mental effects: one crosses and one does not.

Neuroinflammation stimulates

Microglia

The brain's resident immune cell, and the hinge of the whole estrogen protection argument. Estrogen holds these cells in a surveilling state. Remove estrogen and they shift to an activated state and release the cytokines that damage the neurons around them.

Neuronal Apoptosis

Programmed neuron death. Unlike muscle, these cells are largely not replaced, so this process is where a reversible effect becomes a permanent one. Everything protective in this module ultimately resolves to whether it raises or lowers this.

Neuroinflammation suppresses

Synaptic Plasticity

The brain's ability to strengthen and rebuild connections. It is what learning physically is, and it is the endpoint almost every nootropic peptide claims.

Beyond this page

Neuroinflammation also connects to 4 entries in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.

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