Mitochondrial Calcium Buffering
How much calcium a neuron's mitochondria can absorb before the cell dies. This is the single most underrated number in the whole estrogen argument: estradiol does not stop calcium entering the neuron, it raises the amount the neuron can survive.
Relationships
3 connectionsMitochondrial Calcium Buffering reduces risk of
Excitotoxic Injury
Death by over-stimulation. Glutamate opens calcium channels, calcium floods in past what the mitochondria can hold, and the cell triggers its own destruction. It is the final common path for a large share of neuronal death, and it is the exact process estrogen defends against.
Neuronal Apoptosis
Programmed neuron death. Unlike muscle, these cells are largely not replaced, so this process is where a reversible effect becomes a permanent one. Everything protective in this module ultimately resolves to whether it raises or lowers this.
Mitochondrial Calcium Buffering stimulates
Beyond this page
Mitochondrial Calcium Buffering also connects to 1 entry in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.
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