GIP Receptor
GIPRThe second incretin receptor. Adding it to GLP-1 agonism is what separates tirzepatide from semaglutide: more energy expenditure and a direct effect on fat tissue, on top of the appetite drop.
Relationships
3 connectionsGIP Receptor expressed in
Adipose Tissue
Stores fat and houses most of the body's aromatase, so more fat mass means more conversion of androgen to estrogen.
Hypothalamus
The control room above the pituitary. Appetite, body temperature, the reproductive axis and the GH rhythm are all set here, which is why so many peptides that produce whole-body effects act on one small area.
Pancreatic Islet
The insulin and glucagon-producing cells. Incretin drugs raise insulin here only when glucose is already high, which is why they do not cause hypoglycaemia on their own the way injected insulin does.
Beyond this page
GIP Receptor also connects to 2 entries in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.
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