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Dopamine D2 Receptor

D2R
Receptor Cns

The dopamine receptor that holds prolactin down and carries reward and motivation signalling. Losing D2 tone raises prolactin and flattens drive and sexual response.

Relationships

3 connections

Dopamine D2 Receptor agonist of

Dopamine

Neurotransmitter for motivation and movement, and the direct precursor of noradrenaline.

Dopamine D2 Receptor elevates

Dopamine Signalling

How strongly dopamine is signalling, mostly in the reward and motivation circuits. This is the route by which a compound that raises prolactin ends up flattening drive: dopamine holds prolactin down, so a sustained prolactin rise is read backwards as reduced dopaminergic tone.

Dopamine D2 Receptor expressed in

Limbic System

The emotional core of the brain, and androgen-receptor rich. This is where mood, threat response and aggression are set, and where steroid mental effects are thought to land.

Beyond this page

Dopamine D2 Receptor also connects to 1 entry in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.

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